| Immunogen | Felinespinalcordfixedgraymatter. | 
| Epitope | Brain(coreprotein) | 
| Clone | Cat-301 | 
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. | 
| Host | Mouse | 
| Specificity | Chondroitinsulfateproteoglycan(CSPG),braincoreprotein. | 
| Isotype | IgG1 | 
| SpeciesReactivity | - GuineaPig
 - Human
 - Hamster
 - Rat
 - Feline
 - Gerbil
 - Primate
 
  | 
| AntibodyType | MonoclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | Thisgeneisamemberoftheaggrecan/versicanproteoglycanfamily.Theencodedproteinisanintegralpartoftheextracellularmatrixincartilagenoustissueanditwithstandscompressionincartilage.Mutationsinthisgenemaybeinvolvedinskeletaldysplasiaandspinaldegeneration.Multiplealternativelysplicedtranscriptvariantsthatencodedifferentproteinisoformshavebeenobservedinthisgene. | 
| GeneSymbol | - ACAN
 - MSK16
 - SEDK
 - CSPCP
 - AGCAN
 - AGC1
 - CSPG1
 - CSPGCP
 
  | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:P16112#Thisproteoglycanisamajorcomponentofextracellularmatrixofcartilagenoustissues.Amajorfunctionofthisproteinistoresistcompressionincartilage.ItbindsavidlytohyaluronicacidviaanN-terminalglobularregion. SIZE:2415aminoacids;250193Da SUBUNIT:InteractswithFBLN1(Bysimilarity). SUBCELLULARLOCATION:Secreted,extracellularspace,extracellularmatrix(Bysimilarity). TISSUESPECIFICITY:Restrictedtocartilages. DEVELOPMENTALSTAGE:Expressionwasdetectedinchondrocytesthroughoutthedevelopingskeleton. DOMAIN:SwissProt:P16112Twoglobulardomains,G1andG2,comprisetheN-terminusoftheproteoglycan,whileanotherglobularregion,G3,makesuptheC-terminus.G1containsLinkdomainsandthusconsistsofthreedisulfide-bondedloopstructuresdesignatedastheA,B,B"motifs.G2issimilartoG1.Thekeratansulfate(KS)andthechondroitinsulfate(CS)attachmentdomainsliebetweenG2andG3. PTM:Containsmostlychondroitinsulfate,butalsokeratansulfatechains,N-linkedandO-linkedoligosaccharides.Thereleaseofaggrecanfragmentsfromarticularcartilageintothesynovialfluidatallstagesofhumanosteoarthritisistheresultofcleavagebyaggrecanase. DISEASE:SwissProt:P16112#DefectsinAGC1arethecauseofspondyloepiphysealdysplasiatypeKimberley(SEDK)[MIM:608361].Spondyloepiphysealdysplasiasareaheterogeneousgroupofcongenitalchondrodysplasiasthatspecificallyaffectepiphysesandvertebrae.TheautosomaldominantSEDKisassociatedwithprematuredegenerativearthropathy. SIMILARITY:Belongstotheaggrecan/versicanproteoglycanfamily.&Contains1C-typelectindomain.&Contains1EGF-likedomain.&Contains1Ig-likeV-type(immunoglobulin-like)domain.&Contains4Linkdomains.&Contains1Sushi(CCP/SCR)domain. |