| Immunogen | RaisedagainsttheP19subunitofrecombinanthumanCaspase-2protein. | 
| Clone | 10C6 | 
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. | 
| Host | Rat | 
| Specificity | MAB3501antibodyrecognizesareactiveepitopethatliesintheP19subunitofhumanCaspase-2(ICH-1,Nedd-2). | 
| Isotype | IgG2a | 
| SpeciesReactivity |  | 
| AntibodyType | MonoclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | Thisgeneencodesaproteinwhichisamemberofthecysteine-asparticacidprotease(caspase)family.Sequentialactivationofcaspasesplaysacentralroleintheexecution-phaseofcellapoptosis.Caspasesexistasinactiveproenzymeswhichundergoproteolyticprocessingatconservedasparticresiduestoproducetwosubunits,largeandsmall,thatdimerizetoformtheactiveenzyme.Theproteolyticcleavageofthisproteinisinducedbyavarietyofapoptoticstimuli.Alternativesplicingofthisgeneresultsinmultipletranscriptvariantsthatencodedifferentisoforms. | 
| GeneSymbol | - CASP2
 - NEDD2
 - ICH1
 - NEDD-2
 - ICH-1L/1S
 - CASP-2
 - ICH-1L
 - EC3.4.22.55[Contains:Caspase-2subunitp18
 - Caspase-2subunitp13
 - Caspase-2subunitp12].
 
  | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:P42575#InvolvedintheactivationcascadeofcaspasesresponsIBLeforapoptosisexecution.Mightfunctionbyeitheractivatingsomeproteinsrequiredforcelldeathorinactivatingproteinsnecessaryforcellsurvival. SIZE:452aminoacids;50685Da SUBUNIT:Heterotetramerthatconsistsoftwoanti-parallelarrangedheterodimers,eachoneformedbyap18subunitandap12subunit.InteractswithLRDD. TISSUESPECIFICITY:Expressedinlargeramountsintheembryoniclung,liverandkidneythanintheheartandbrain.Intheadultshigherlevelexpressionisseenintheplacenta,lung,kidney,pancreasthanintheheart,brain,liverandskeletalmuscle. PTM:Thematureproteasecanprocessitsownpropeptide,butnotthatofothercaspases. SIMILARITY:SwissProt:P42575##BelongstothepeptidaseC14family.&Contains1CARDdomain. |