| Immunogen | Purifiedglialfilamentprotein(Debus,E.,1983). | 
| Host | Mouse | 
| Specificity | TheantibodyreactswithmouseGFAP.Intissuesectionsthis antibodystainsastrocytesandBergmangliacells(Debus,E.,1983).
 | 
| Isotype | IgG1 | 
| SpeciesReactivity |  | 
| SpeciesReactivityNote | DemonstratedtoreactwithMouse.PredictedtoreactwithHuman,Rat,Porcine,andChickenbasedon100%sequencehomology. | 
| AntibodyType | MonoclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | Thisgeneencodesoneofthemajorintermediatefilamentproteinsofmatureastrocytes.Itisusedasamarkertodistinguishastrocytesfromotherglialcellsduringdevelopment.MutationsinthisgenecauseAlexanderdisease,araredisorderofastrocytesinthecentralnervoussystem.Alternativesplicingresultsinmultipletranscriptvariantsencodingdistinctisoforms.[providedbyRefSeq]. | 
| GeneSymbol |  | 
| PurificationMethod | ProteinAPurfied | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:GFAP,aclass-IIIintermediatefilament,isacell-specificmarkerthat,duringthedevelopmentofthecentralnervoussystem,distinguishesastrocytesfromotherglialcells. 
 SIZE:432aminoacids;49880Da
 
 SUBUNIT:Isoform3interactswithN-terminusofPSEN1.
 
 SUBCELLULARLOCATION:Cytoplasm.Note=Associatedwithintermediatefilaments.
 
 DISEASE:DefectsinGFAPareacauseofAlexanderdisease[MIM:203450].Alexanderdiseaseisararedisorderofthecentralnervoussystem.ItisaprogressiveleukoencephalopathywhosehallmarkisthewidespreadaccumulationofRosenthalfiberswhicharecytoplasmicinclusionsinastrocytes.Themostcommonformaffectsinfantsandyoungchildren,andischaracterizedbyprogressivefailureofcentralmyelination,usuallyleADIngtodeathusuallywithinthefirstdecade.InfantswithAlexanderdiseasedevelopaleukoencephalopathywithmacrocephaly,seizures,andpsychomotorretardation.Patientswithjuvenileoradultformstypicallyexperienceataxia,bulbarsignsandspasticity,andamoreslowlyprogressivecourse.
 
 SIMILARITY:Belongstotheintermediatefilamentfamily.
 | 
| MolecularWeight | 50kDaObserved(UsingunconjugatedantibodyMAB3402) |