| Immunogen | Humanpheochromocytoma | 
| Clone | PHE5 | 
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. | 
| Host | Mouse | 
| Specificity | ChromograninA.Theantibodyhasbeenextensivelydocumentedonimmunohistochemicalstudiesindeparaffinizedmethacarnfixedtissue,whereitisasensitiveMarkerofneuroendocrinecellsandtumors.Notrecommendedforformalinfixedtissues,seeMAB5268orCBL219.Onwesternblots,itidentifiestheidenticalbandsrecognizedbyantibodyLK2H10(WilsonandLloyd). | 
| Isotype | IgG1 | 
| SpeciesReactivity |  | 
| AntibodyType | MonoclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | Theproteinencodedbythisgeneisamemberofthechromogranin/secretograninfamilyofneuroendocrinesecretoryproteins.Itisfoundinsecretoryvesiclesofneuronsandendocrinecells.Thisgeneproductisaprecursortothreebiologicallyactivepeptides;vasostatin,pancreastatin,andparastatin.Thesepeptidesactasautocrineorparacrinenegativemodulatorsoftheneuroendocrinesystem.Otherpeptides,includingchromostatin,beta-granin,WE-14andGE-25,arealsoderivedfromthefull-lengthprotein.However,biologicalactivitiesforthesemoleculeshavenotbeenshown. | 
| GeneSymbol |  | 
| Non-ReactiveSpecies |  | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:P10645#Pancreastatinstronglyinhibitsglucoseinducedinsulinreleasefromthepancreas. SIZE:457aminoacids;50730Da
 SUBCELLULARLOCATION:Secreted.Note=Neuroendocrineandendocrinesecretorygranules.
 PTM:Sulfatedontyrosineresiduesand/orcontainssulfatedglycans.
 SIMILARITY:SwissProt:P10645##Belongstothechromogranin/secretograninproteinfamily.
 MISCELLANEOUS:Bindscalciumwithalow-affinity.
 |