| Immunogen | Glutaminesynthetasepurifiedfromsheepbrain. | 
| Clone | GS-6 | 
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. | 
| Host | Mouse | 
| Specificity | ReactsstronglywithasinglebandonWesternblotsofsheepbrainandratbrain.Glutaminesynthetase,anenzymethatcatalyzestheaminationofglutamicacidtoformglutamine,isfoundinmammalsasanoctamerofeightidentical45kDasubunits.GlutaminesynthetaseactivityhasbeenshowntobeausefulMarkerofastrocytesandanimportantdifferentiationfeatureinretina.Glutaminesynthetaseisalsoconsideredtobeakeyenzymeintherecyclingoftheneurotransmitterglutamate. | 
| Isotype | IgG2a | 
| SpeciesReactivity |  | 
| AntibodyType | MonoclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | Glutamineisamainsourceofenergyandisinvolvedincellproliferation,inhibitionofapoptosis,andcellsignaling(Haberleetal.,2005[PubMed16267323]).Fetalglutaminerequirementsareveryhighanddependlargelyonactiveglutaminesynthesisandthereleaseofglutamineintothefetalcirculationbytheplacenta.Glutaminesynthetase(EC6.3.1.2),alsocalledglutamate-ammonialigase(GLUL),isexpressedthroughoutthebodyandplaysanimportantroleincontrollingbodypHandinremovingammoniafromthecirculation.TheenzymeclearsL-glutamate,themajorneurotransmitterinthecentralnervoussystem,fromneuronalsynapses(seereferencesinClancyetal.,1996[PubMed8975719]).[suppliedbyOMIM] | 
| GeneSymbol |  | 
| PurificationMethod | ProteinAPurfied | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:P15104#CatalyzestheconversionofammoniaandL-glutamatetoL-glutamine. SIZE:373aminoacids;42064Da
 SUBUNIT:Homooctamer.
 SUBCELLULARLOCATION:Cytoplasm.
 DISEASE:SwissProt:P15104#DefectsinGLULarethecauseofcongenitalsystemicglutaminedeficiency(CSGD)[MIM:610015].CSGDisararedevelopmentaldisorderwithseverebrainmalformationresultinginmulti-organfailureandneonataldeath.Glutamineislargelyabsentfromaffectedpatientsserum,urineandcerebrospinalfluid.
 SIMILARITY:SwissProt:P15104##Belongstotheglutaminesynthetasefamily.
 | 
| MolecularWeight | 45kDa |