| Immunogen | IL-1betaactivatedHUVEC(human) | 
| Clone | P8G6 | 
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. | 
| Host | Mouse | 
| Specificity | HumanPSelectin | 
| Isotype | IgG1 | 
| SpeciesReactivity |  | 
| AntibodyType | MonoclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | SELPLGisthehighaffinitycounter-receptorforP-selectinonmyeloidcellsandstimulatedTlymphocytes.Assuch,itplaysacriticalroleinthetetheringofthesecellstoactivatedplateletsorendotheliaexpressingP-selectin.TheorganizationoftheSELPGgenecloselyresemblesthatofCD43andthehumanplateletglycoproteinGpIb-alphabothofwhichhaveanintroninthe5-prime-noncodingregion,alongsecondexoncontainingthecompletecodingregion,andTATA-lesspromoters. | 
| GeneSymbol | SELPLGCLAPSGL-1CD162PSGL1
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| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:Q14242#BindstoP-,E-andL-selectins.Thecalcium-dependenthighaffinityinteractionwithP-selectinmediatesthetetheringandrollingofneutrophilsandT-lymphocytesonendothelialcells. SIZE:412aminoacids;43201Da
 SUBUNIT:Homodimer;disulfide-linked.
 SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein.
 TISSUESPECIFICITY:Expressedonneutrophils,monocytesandmostlymphocytes.
 PTM:Displayscomplex,sialylatedandfucosylatedO-linkedoligosaccharides,atleastsomeofwhichappeartocontainpoly-N-acetyllactosaminewithvaryingdegreesofsubstitution.AlsoN-glycosylated.&SulfatedintheN-terminalregion;sulfationisnecessaryforP-selectinbinding.
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