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Millipore/MAB1596 | Anti-Post Synaptic Density Protein 95 Antibody, clone 6G6-1C9/MAB1596/100 µg
  • Millipore/MAB1596 | Anti-Post Synaptic Density Protein 95 Antibody, clone 6G6-1C9/MAB1596/100 µg

Millipore/MAB1596 | Anti-Post Synaptic Density Protein 95 Antibody, clone 6G6-1C9/MAB1596/100 µg

價(jià)格: ￥4812.00 市場(chǎng)價(jià): 8020.00
貨號(hào): MAB1596
品牌: Millipore
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    • Description
      CatalogueNumberMAB1596
      Replaces04-1066
      BrandFamilyChemicon®
      TradeName
      • Chemicon
      DescriptionAnti-PostSynapticDensityProtein95Antibody,clone6G6-1C9
      AlternateNames
      • PSD-95
      BackgroundInformationPSD-95ispartofamultiproteincomplexrestrictedtothepost-synapticmembrane.ItisbelievedtoinitiateNMDAreceptorclusteringonthepostsynapticmembrane.ItsrestrictedexpressionmakesitanexcellentMarkerforpost-synapticmembraneregionsonneurons.
      ProductInformation
      FormatPurified
      Control
      • Mousebrain,ratbraintissue.
      PresentationPurifiedimmunoglobulin.LiquidinPBS,pH7.2with50%glyceroland0.09%sodiumazide.
      StorageandShippingInformation
      StorageConditionsStablefor6monthsat-20°Cinundilutedaliquotsfromdateofreceipt.Donotstorebelow-20°C.
      HandlingRecommendations:Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:VariABIllityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage.
      Applications
      ApplicationAnti-PostSynapticDensityProtein95Antibody,clone6G6-1C9detectslevelofPostSynapticDensityProtein95&hasbeenpublished&validatedforuseinIC,IH&WB.
      KeyApplications
      • Immunocytochemistry
      • Immunohistochemistry
      • WesternBlotting
      ApplicationNotesImmunocytochemistry:
      Representativeimagefromapreviouslot.
      ConfocalfluorescentanalysisofPC12usingMAb1596MousemAB(Red).ActinfilamentshavebeenlabeledwithAlexaFluor488-Phalloidin(Green).NuclearisstainedwithDAPI(Blue).Membranestainingpositive.

      Immunocytochemistry:
      12.5μg/mL

      WesternBlot:
      1-5μg/mL(ECL)onratbrainlysate(20μg).

      Optimalworkingdilutionsmustbedeterminedbytheenduser.
      BIOLOGicalInformation
      ImmunogenRecombinantratPSD-95.
      Clone6G6-1C9
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostMouse
      SpecificityReactswithaproteinof~100kDa,correspondingtotheapparentmolecularweightofPSD-95,onSDS-PAGEimmunoblotsofsamplesfromrat,mouseandbovine.Aslightlyhighermolecularweightbandisalsodetected.Inratbrainandmousebraintissueextractsabandof~75kDaisalsopresent.
      IsotypeIgG2a
      SpeciesReactivity
      • Bovine
      • Mouse
      • Rat
      SpeciesReactivityNoteRat,mouseandbovine.Otherspecieshavenotbeentested.
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThisgeneencodesamemberofthemembrane-associatedguanylatekinase(MAGUK)family.ItheteromultimerizeswithanotherMAGUKprotein,DLG2,andisrecruitedintoNMDAreceptorandpotassiumchannelclusters.ThesetwoMAGUKproteinsmayinteractatpostsynapticsitestoformamultimericscaffoldfortheclusteringofreceptors,ionchannels,andassociatedsignalingproteins.Multipletranscriptvariantsencodingdifferentisoformshavebeenfoundforthisgene.[providedbyRefSeq]
      GeneSymbol
      • PSD-95
      PurificationMethodSeedatasheetforpurificationmethod.
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P78352#InteractswiththecytoplasmictailofNMDAreceptorsubunitsandshaker-typepotassiumchannels.RequiredforsynapticplasticityassociatedwithNMDAreceptorsignaling.OverexpressionordepletionofDLG4changestheratioofexcitatorytoinhibitorysynapsesinhippocampalneurons.MayreducetheamplitudeofACCN3acid-evokedcurrentsbyretainingthechannelintracellularly.MayregulatetheintracellulartraffickingofADR1B(Bysimilarity).
      SIZE:724aminoacids;80495Da
      SUBUNIT:InteractsthroughitsfirsttwoPDZdomainswithGRIN2A,GRIN2B,GRIN2C,GRIN2D,ACCN3,certainspliceformsofGRIN1,KCND2,CXADRandSYNGAP1.InteractsthroughitssecondPDZdomainwiththePDZdomainofNOS1ortheC-terminusofCAPON.MayinteractwithHTR2A.Interactsthroughitsguanylatekinase-likedomainwithDLGAP1/GKAP,DLGAP2,DLGAP3,DLGAP4,MAP1A,andBEGAIN(Bysimilarity).InteractsthroughitsfirsttwoPDZdomainswithKCNA1,KCNA2,KCNA3,KCNA4andERBB4.InteractsthroughitsfirstPDZdomainwithGRIK2,KCNA4andCRIPT.InteractsthroughitsthirdPDZdomainwithNLGN1,andprobablywithNLGN2andNLGN3.Interactsthroughitsguanylatekinase-likedomainwithKIF13B.Isoform2interactsthroughanL27domainwithHGS/HRSandthefirstL27domainofCASK.
      SUBCELLULARLOCATION:Cellmembrane;Peripheralmembraneprotein.Celljunction,synapse,postsynapticcellmembrane,postsynapticdensity.Celljunction,synapse.Note=Highlevelsinpostsynapticdensityofneuronsintheforebrain.AlsoinpresynapticregionofinhibitorysynapsesformedbycerebellarbasketcellsonaxonhillocksofPurkinjecells.
      TISSUESPECIFICITY:Brain.
      DOMAIN:SwissProt:P78352ThePDZdomain3mediatesinteractionwithADR1B.&TheL27domainneartheN-terminusofisoform2isrequiredforHGS/HRS-dependenttargetingtopost-synapticdensity.
      PTM:Palmitoylationofisoform1isrequiredfortargetingtopostsynapticdensity(Bysimilarity).
      SIMILARITY:BelongstotheMAGUKfamily.&Contains1guanylatekinase-likedomain.&Contains3PDZ(DHR)domains.&Contains1SH3domain.
      MolecularWeight~100kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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