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Millipore/FCCS025210 | FlowCellect? PI3K-mTOR Signaling Cascade kit /FCCS025210/25 Tests / Kit
  • Millipore/FCCS025210 | FlowCellect? PI3K-mTOR Signaling Cascade kit /FCCS025210/25 Tests / Kit

Millipore/FCCS025210 | FlowCellect? PI3K-mTOR Signaling Cascade kit /FCCS025210/25 Tests / Kit

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貨號: FCCS025210
品牌: Millipore
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    • Description
      CatalogueNumberFCCS025210
      TradeName
      • FlowCellect
      DescriptionFlowCellect?PI3K-mTORSignalingCascadekit
      OverviewSignalingthroughthePI3K/Akt/mTORpathwayisconstitutivelyactiveinmanycancercellsduetothelossofPTEN(tumorsuppressor),exposuretocarcinogens,activationofgrowthreceptors,aswellasmutationsoramplificationsofPI3KorAkt.Therelevanceofthispathwayindifficulttotreatcancersmakesthesessignalingnodesprimetargetsinadvancinganticancertherapies.

      Millipore’sFlowCellect?PI3K-mTORAnalysisKitincludestwodirectlyconjugatedphospho-specificsignalingantibodieswhichareoptimizedformulti-colorflowcytometryapplicationstoanalyzethemTORpathwayingreatdetail.ThephosphorylationofAktisindicativeoftheupstreamPI3Ksignaling,markingthecellsinitiationintoproliferationorcellsurvival.Phosporylated-RibosomalS6proteinisindicativeofdownstreammTORandp70S6KsignalingleADIngtoproteintranslation.

      Byprovidingbothoftheseantibodiesinonekit,theresearcherhasthecompletesolutionwhenexaminingthemTORpathwaywhichisbeneficialfortheelucidationofdrugeffectivenessintheircancerresearch.
      AlternateNames
      • FlowCellect
      BackgroundInformationExaminationofcellsignalingpathwaysandmonitoringtheiractivationstatushavebeenextremelyimportantforresearcherstounderstandthedetailedmechanismsofcellularfunctionsandthecauseofvariousdiseases.Manysignaltransductionpathwayshavebeenimplicatedtoleadtomultipleoutcomessuchasapoptosis,celldifferentiation,cellgrowthandcellproliferation,allofwhichhavebeenextensivelystudiedforthetreatmentofvariouscancersandautoimmunediseases.

      Thestudyofcellsignalingpathwaysarenowmadeeasierwiththeuseofactivationstatus-specificandphospho-specificantibodies.Measurementofproteinphosphorylationwithphospho-specificantibodieshasgiveninsightintokinasesignalingcascades[Krutzik,P.O.etal.(2003].Multi-parameterphosphoflowcytometryisapowerfultoolforstudyingmultiplepathwaysinamixedcellpopulationatthesametime.

      Milliporeoffersarangeofnovelantibodybasedmulti-parameterFlowCellect?kitswhicharespecificallydesignedtoaddressthecurrentneedsinphosphoflowcytometryanalysisofcellsignalingpathwaysandcancerresearchinamulti-parametricfashion.Alloftheantibodiesprovidedinthekithavebeendirectlyconjugatedandoptimizedformulti-colorflowcytometryapplications.Byusingacombinationofantibodiesprovidedinthekit,researcherscannowaccuratelymeasurekeysignalingnodesandendpointsactivations.Moreover,researcherscanalsodissectanyparticularlinearsignalingpathwaycascadebymeasuringtheactivationofseveralcomponentsinatimecoursedependentmanner.ByusingtheFlowCellect?PI3K-mTORSignalingCascadekit,theresearchercannowstudymTORingreaterdetailanditsrelationshipingeneralcellfunctionsuchascellproliferation,apoptosisandcancer.

      AllFlowCellect?kitsareoptimizedonthebench-topGuava?flowcytometrysystems,whichsavesvaluabletimeandsamplevolume.Allkitscontainoptimizedfixation,permeABIlization,washandflowbufferstoprovideresearcherswithacompletesolutionforsimultaneousdetectionofmultiplepathwayactivations.WiththeGuavaplatformandFlowCellect?kits,onecanfinallyhaveaneasy,reliableandfullyvalidatedsolutiontostudythecomplexcellsignalingpathwaysrightinthecomfortofyourownlab.
      ProductInformation
      Components
      • 1.20XAnti-phospho-RibosomalProteinS6(Ser235)PerCPconjugateMonoclonalAntibody:(PartNo.CS203308)One150μLvial
      • 2.20XAnti-phospho-Akt1/PKBα(Ser473)AlexaFluor488conjugateMonoclonalAntibody:(PartNo.CS203310)One150μLvial
      • 3.FixationBuffer:(PartNo.CS202122)One13mLbottle
      • 4.10XWashBuffer:(PartNo.CS202123)One13mLbottle
      • 5.5XAssayBuffer:(PartNo.CS202124)One55mLbottle
      • 6.1XPermeabilizationBuffer:(PartNo.CS203284)Two13mLbottles
      Detectionmethod125IFluorescent
      StorageandShippingInformation
      StorageConditions4-8°Cforantibodiesandbuffers
      Applications
      ApplicationThisFlowCellectPI3K-mTORAnalysisKitincludestwodirectlyconjugatedphospho-specificsignalingantibodieswhichareoptimizedformulti-colorflowcytometryapplicationstoanalyzethemTORpathwayingreatdetail.
      KeyApplications
      • FlowCytometry
      BIOLOGicalInformation
      HostRabbit/Murine
      SpeciesReactivity
      • Human
      AntibodyTypeMonoclonalAntibody
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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