| CatalogueNumber | CC117 | 
| BrandFamily | Chemicon®
  | 
| TradeName |  | 
| Description | ChickenExtracellularChondroitinSulfateProteoglycans | 
| Overview | DESCRIPTION/COMPOSITION:CC117containsamixtureoflarge,extracellularchondroitinsulfateproteoglycansisolatedfromembryonicchickenbrain.Aminoacidsequenceanalysesandimmunologicalstudieshavedemonstratedthatthemajorcomponentsofthismixtureareneurocan,phosphacan,versican,andaggrecan.Followingchondroitinasetreatmenttoremovetheglycosaminoglycanportionoftheseproteoglycans,themajorcomponentsofthispreparationresolvedonSDSgelsare250kDacoreproteinsrepresentingneurocanand400kDacoreproteinsrepresentingaggrecan,phosphacan,andversican.
  *Quantity:Proteinasdeterminedusingthebicinchoninicacid(BCA)assay.Notethat100μgisameasurementofcorepolypeptides.Componentsofthismixturecontaincorepolypeptideplusattachedglycosaminoglycans | 
| BackgroundInformation | Aggrecan,versican,andneurocanaremembersofthefamilyofhyaluronicacid-bindingproteoglycansandthereforeeachcontainshyaluronicacidbindingregions,Ig-likedomains,EGFlikedomains,lectin-likedomains,andcomplementregulatory-likedomains.Phosphacanisdistinct;itcontainsaregionofsimilaritytocarbonicanhydrase,afibronectintypeIIIdomain,andisasplicevariantofthetransmembraneproteinreceptortyrosinephosphataseequivalenttoitsextracellularportion.
  AlthoughaggrecanwastrADItionallythoughtofasacartilageproteoglycanandneurocanandphosphacanwerethoughtofasneuralproteoglycans,recentstudiesindicatethatallfouroftheseproteoglycanshavebroadyetdistinctivedistributionpatternsinearlyembryos.Thepresenceoftheseproteoglycanshasnotbeencarefullyexaminedinadulttissuebeyondtheexpectedsites.Theseproteoglycansareanti-adhesionmoleculesandarecapableofinhibitingbothcell-ECMandcell-celladhesion. |