| Immunogen | Syntheticpeptidethatcorrespondstoaminoacids325-342oftheC-terminusofthehumanMSRtypeI. | 
| Host | Goat | 
| Specificity | SpecificforhumanmacrophagescavengerreceptortypeI(MSRtypeI).Thisantibodyimmunolabelsamyloidplaquesinformalin-fixedparaffinsectionsfromAlzheimer"sDisease(AD)brain. | 
| SpeciesReactivity |  | 
| AntibodyType | PolyclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | ThisgeneencodestheclassAmacrophagescavengerreceptors,whichincludethreedifferenttypes(1,2,3)generatedbyalternativesplicingofthisgene.Thesereceptorsorisoformsaremacrophage-specifictrimericintegralmembraneglycoproteinsandhavebeenimplicatedinmanymacrophage-associatedphysiologicalandpathologicalprocessesincludingatherosclerosis,Alzheimer"sdisease,andhostdefense.Theisoformstype1andtype2arefunctionalreceptorsandareabletomediatetheendocytosisofmodifiedlowdensitylipoproteins(LDLs).Theisoformtype3doesnotinternalizemodifiedLDL(acetyl-LDL)despitehavingthedomainshowntomediatethisfunctioninthetypes1and2isoforms.Ithasanalteredintracellularprocessingandistrappedwithintheendoplasmicreticulum,makingitunabletoperformendocytosis.Theisoformtype3caninhibitthefunctionofisoformstype1andtype2whenco-expressed,indicatingadominantnegativeeffectandsuggestingamechanismforregulationofscavengerreceptoractivityinmacrophages. | 
| GeneSymbol | - MSR1
 - SR-A
 - SCARA1
 - phSR2
 - phSR1
 - CD204
 
  | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:P21757#Membraneglycoproteinsimplicatedinthepathologicdepositionofcholesterolinarterialwallsduringatherogenesis.Twotypesofreceptorsubunitsexist.Thesereceptorsmediatetheendocytosisofadiversegroupofmacromolecules,includingmodifiedlowdensitylipoproteins(LDL). SIZE:451aminoacids;49762Da SUBUNIT:Homotrimer. SUBCELLULARLOCATION:Membrane;Single-passtypeIImembraneprotein. SIMILARITY:SwissProt:P21757##Contains1collagen-likedomain.&Contains1SRCRdomain. |