| Immunogen | Peptidecorrespondingtotheaminoacids11-26ofhumana,b,andg(82%)-synucleinprotein.Thepeptidewaschosensothattheantibodywouldrecognizeallthreeformsofsynuclein. | 
| Host | Rabbit | 
| Specificity | Pansynuclein.Initialtestingbyimmunohistochemistryindicatesthattheantibodystainingpatternoverlapsalpha,beta,andgamma-synucleinmaps. | 
| SpeciesReactivity |  | 
| AntibodyType | PolyclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | Theproteinencodedbythisgeneishighlyhomologoustoalpha-synuclein.TheseproteinsareabundantlyexpressedinthebrainandputativelyinhibitphospholipaseD2selectively.Theencodedprotein,whichmayplayaroleinneuronalplasticity,isabundantinneurofibrillarylesionsofpatientswithAlzheimerdisease.Thisproteinhasbeenshowntobehighlyexpressedinthesubstantianigraofthebrain,aregionofneuronaldegenerationinpatientswithParkinsondisease;however,nodirectrelationtoParkinsondiseasehasbeenestablished.Twotranscriptvariantsencodingthesameproteinhavebeenfoundforthisgene. | 
| GeneSymbol | - SNCA
 - PD1
 - alpha-synuclein
 - NACP
 - PARK4
 - MGC110988
 - PARK1
 - Alpha-synuclein
 
  | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:Q16143#Non-amyloidcomponentofsenileplaquesfoundinAlzheimerdisease.CouldactasaregulatorofSNCAaggregationprocess.Protectsneuronsfromstaurosporineand6hydroxydopamine(6OHDA)-stimulatedcaspaseactivationinap53-dependentmanner.ContributestorestoretheSNCAanti-apoptoticfunctionabolishedby6OHDA.NotfoundintheLewybodiesassociatedwithParkinsondisease. SIZE:134aminoacids;14288Da SUBCELLULARLOCATION:Cytoplasm. TISSUESPECIFICITY:Expressedpredominantlyinbrain;concentratedinpresynapticnerveterminals. PTM:Phosphorylated.PhosphorylationbyG-proteincoupledreceptorkinases(GRK)ismoreefficientthanphosphorylationbyCK1,CK2andCaM-kinaseII. DISEASE:SwissProt:Q16143#Brainironaccumulationtype1(NBIA1,alsocalledHallervorden-Spatzsyndrome),arareneuroaxonaldystrophy,ishistologicallycharacterizedbyaxonalspheroids,irondeposition,Lewybody(LB)-likeintraneuronalinclusions,glialinclusionsandneurofibrillarytangles.SNCBisfoundinspheroidsbutnotininclusions. SIMILARITY:SwissProt:Q16143##Belongstothesynucleinfamily. |