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Millipore/AB1554 | Anti-Nerve Growth Factor Receptor Antibody, p75/AB1554/100 µL
  • Millipore/AB1554 | Anti-Nerve Growth Factor Receptor Antibody, p75/AB1554/100 µL

Millipore/AB1554 | Anti-Nerve Growth Factor Receptor Antibody, p75/AB1554/100 µL

價(jià)格: ￥4440.00 市場(chǎng)價(jià): 7400.00
貨號(hào): AB1554
品牌: Millipore
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    • Description
      CatalogueNumberAB1554
      Replaces04-1111
      BrandFamilyChemicon®
      TradeName
      • Chemicon
      DescriptionAnti-NerveGrowthFactorReceptorAntibody,p75
      AlternateNames
      • CD271antigen
      • Lowaffinityneurotrophinreceptorp75NTR
      • Low-affinitynervegrowthfactorreceptor
      • NGFreceptor
      • lowaffinitynervegrowthfactorreceptor
      • nervegrowthfactorreceptor
      • nervegrowthfactorreceptor(TNFRsuperfamily,member16)
      • p75ICD
      BackgroundInformationNerveGrowthFactorReceptor,alsotermedNGFRp75,p75NTR,orCD271isthelowaffinityNGFR(LNGFR)whichbindsNGFandotherneurotrophinsincludingBDNF,NT3,NT4/5withsimilar,lowaffinity.NGFRp75isa75kDatransmembraneglycoprotein(399a.a.)consistingofanextracellulardomain(222a.a.)whichcontainsfourcysteinerichdomainsresponsIBLeforligandbinding,atransmembranedomain(22a.a.),andacytoplasmicdomain(155a.a.).NGFRp75ismainlyexpressedinSchwanncellsandneuronsandinavarietyofnonneuronalcells.NGFRp75isnecessaryforregulatingneuronalgrowth,migration,differentiationandcelldeathduringdevelopmentofthecentralandperipheralnervoussystem.NGFRp75playsacentralroleintheregulationofcellnumberbyapoptosisinthedevelopingCNS.
      ProductInformation
      FormatSerum
      Control
      • RatPC12cells.
      PresentationRabbitpolyclonalserumcontaining0.05%NaN3.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20oCfromdateofreceipt.
      Applications
      ApplicationAnti-NerveGrowthFactorReceptorAntibody,p75isanantibodyagainstNerveGrowthFactorReceptorforuseinIC,IH(P),andIP.
      KeyApplications
      • Immunocytochemistry
      • Immunohistochemistry(Paraffin)
      • Immunoprecipitation
      ApplicationNotesImmunoprecipitation:
      1:500-1:5000dilutionofthisantibodyimmunoprecipitatedNGFReceptorp75from10μgofPC12celllysate.

      Immunohistochemistry(paraffin):
      1:50and1:300dilutionfromapreviouslotdetectedNGFReceptorp75usingIHC-SelectDetectionwithHRP-DAB.

      Immunocytochemistry:
      1:500dilutionfromapreviouslotdetectedNGFReceptorp75inratPC12cells.
      BIOLOGicalInformation
      ImmunogenRecombinantmouseNGFReceptorp75extracellularfragment.
      Epitopeextracellular
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      Specificityp75nervegrowthfactorreceptor(p75Neurotrophinreceptor,lowaffinityneurotrophinreceptor),extracellulardomain.
      SpeciesReactivity
      • Human
      • Mouse
      • Rat
      SpeciesReactivityNoteIthasbeenreportedthatthisantibodydoesnotrecognizeratp75byWesternblot.SeeMAB365forratreactiveantibodyusingWesternblotting.
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryNervegrowthfactorreceptorcontainsanextracellulardomaincontainingfour40-aminoacidrepeatswith6cysteineresiduesatconservedpositionsfollowedbyaserine/threonine-richregion,asingletransmembranedomain,anda155-aminoacidcytoplasmicdomain.Thecysteine-richregioncontainsthenervegrowthfactorbindingdomain.
      GeneSymbol
      • NGFR
      • p75(NTR)
      • TNFRSF16
      • Gp80-LNGFR
      • CD271
      PurificationMethodUnpurified
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P08138#LowaffinityreceptorwhichcanbindtoNGF,BDNF,NT-3,andNT-4.Canmediatecellsurvivalaswellascelldeathofneuralcells.
      SIZE:427aminoacids;45183Da
      SUBUNIT:Homodimer;disulfide-linked.Interactswithp75NTR-associatedcelldeathexecutor.InteractswithTRAF2,TRAF4,TRAF6,PTPN13andRANBP9.InteractsthroughTRAF6withSQSTM1whichbridgesNGFRtoNTRK1.InteractswithBEX1andNGFRAP1/BEX3.
      SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein.
      DOMAIN:SwissProt:P08138DeathdomainisresponsibleforinteractionwithRANBP9.
      PTM:N-andO-glycosylated.&O-linkedglycansconsistofGal(1-3)GalNAccoreelongatedby1or2NeuNAc.&Phosphorylatedonserineresidues.
      SIMILARITY:Contains1deathdomain.&Contains4TNFR-Cysrepeats.
      MolecularWeight44.7kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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