| Immunogen | KLHconjugatedsyntheticpeptidecorrespondingtoaminoacidssurroundingTyr284ofhumanACK1. | 
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. | 
| Host | Rabbit | 
| Specificity | RecognizesACK1phosphorylatedonTyrosineresidue284. | 
| Isotype | IgG | 
| SpeciesReactivity |  | 
| AntibodyType | PolyclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | ThisgeneencodesatyrosinekinasethatbindsCdc42HsinitsGTP-boundformandinhibitsboththeintrinsicandGTPase-activatingprotein(GAP)-stimulatedGTPaseactivityofCdc42Hs.Thisbindingismediatedbyauniquesequenceof47aminoacidsC-terminaltoanSH3domain.TheproteinmaybeinvolvedinaregulatorymechanismthatsustainstheGTP-boundactiveformofCdc42Hsandwhichisdirectlylinkedtoatyrosinephosphorylationsignaltransductionpathway.Severalalternativelysplicedtranscriptvariantshavebeenidentifiedfromthisgene,butthefull-lengthnatureofonlytwotranscriptvariantshasbeendetermined. | 
| GeneSymbol | - TNK2
 - p21cdc42Hs
 - ACK1
 - ACK-1
 - FLJ45547
 - FLJ44758
 - ACK
 
  | 
| Modifications |  | 
| PurificationMethod | ImmunoAffinityPurified | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:Q07912#DownstreameffectorofCDC42whichmediatesCDC42-dependentcellmigrationviaphosphorylationofBCAR1.Bindstobothpoly-andmono-ubiquitinandregulatesligand-induceddegradationofEGFR.Participatesinclathrin-mediatedendocytosis.Maybeinvolvedbothinadultsynapticfunctionandplasticityandinbraindevelopment. COFACTOR:Magnesium. SIZE:1036aminoacids;114327Da SUBUNIT:InteractswithCDC42.InteractswithactivatedCSPG4. SUBCELLULARLOCATION:Cellmembrane(Bysimilarity). SIMILARITY:SwissProt:Q07912##Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.&Contains1CRIBdomain.&Contains1proteinkinasedomain.&Contains1SH3domain. | 
| MolecularWeight | 114kDa |