| Immunogen | KLH-conjugated,syntheticpeptidecorrespondingtoaminoacids161-175(KPDVLSQPEAMDDFI)ofhumanACK1 | 
| Host | Rabbit | 
| Specificity | ACK1(Activatedcdc42-associatedKinase1),alsoknownasTNK2(TyrosineKinase,Non-Receptor,2) | 
| Isotype | IgG | 
| SpeciesReactivity | BovineCanineHumanMouseRat
 | 
| AntibodyType | PolyclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | ThisgeneencodesatyrosinekinasethatbindsCdc42HsinitsGTP-boundformandinhibitsboththeintrinsicandGTPase-activatingprotein(GAP)-stimulatedGTPaseactivityofCdc42Hs.Thisbindingismediatedbyauniquesequenceof47aminoacidsC-terminaltoanSH3domain.TheproteinmaybeinvolvedinaregulatorymechanismthatsustainstheGTP-boundactiveformofCdc42Hsandwhichisdirectlylinkedtoatyrosinephosphorylationsignaltransductionpathway.Severalalternativelysplicedtranscriptvariantshavebeenidentifiedfromthisgene,butthefull-lengthnatureofonlytwotranscriptvariantshasbeendetermined. | 
| GeneSymbol | TNK2p21cdc42HsACK1ACK-1FLJ45547FLJ44758ACK
 | 
| PurificationMethod | ImmunoAffinityPurified | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:Q07912#DownstreameffectorofCDC42whichmediatesCDC42-dependentcellmigrationviaphosphorylationofBCAR1.Bindstobothpoly-andmono-ubiquitinandregulatesligand-induceddegradationofEGFR.Participatesinclathrin-mediatedendocytosis.Maybeinvolvedbothinadultsynapticfunctionandplasticityandinbraindevelopment. COFACTOR:Magnesium.
 SIZE:1036aminoacids;114327Da
 SUBUNIT:InteractswithCDC42.InteractswithactivatedCSPG4.
 SUBCELLULARLOCATION:Cellmembrane(Bysimilarity).
 SIMILARITY:SwissProt:Q07912##Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.&Contains1CRIBdomain.&Contains1proteinkinasedomain.&Contains1SH3domain.
 | 
| MolecularWeight | 110kDa |