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Millipore/07-2162 | Anti-PCNA Antibody/07-2162/100 µg
  • Millipore/07-2162 | Anti-PCNA Antibody/07-2162/100 µg

Millipore/07-2162 | Anti-PCNA Antibody/07-2162/100 µg

價(jià)格: ￥3324.00 市場(chǎng)價(jià): 5540.00
貨號(hào): 07-2162
品牌: Millipore
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    • Description
      CatalogueNumber07-2162
      DescriptionAnti-PCNAAntibody
      AlternateNames
      • proliferatingcellnuclearantigen
      • cyclin
      • DNApolymerasedeltaauxiliaryprotein
      • Cyclin
      BackgroundInformationProliferatingcellnuclearantigen(PCNA)belongstotheDNAslidingclampfamilyandiscomprisedofthreeidenticalmonomersformingaheterodimer.Duetoitsuniquestructure,PCNAisabletoincreasetheprocessivityofDNApolymerasedeltabyusingitsouterdomainstobeinvolvedinprotein-proteininteractionwhilestilltetheredtoandfreelyslidingalongtheDNA.PCNAisacriticalregulatorycomponentintheonsetofleADIngstrandDNAreplicationandtheterminationoflaggingstrandsynthesis.StudieshavealsoindicatedaroleforPCNAintherecruitmentandregulationofMMRpathwayrepairproteins.PCNAisalsoabletointeractwithawidevarietyofcellcycleproteinsandservestocoordinateseveralproteinsparticipatinginDNAprocesses,suchasapoptosis.
      ProductInformation
      FormatPurified
      Control
      • A431celllysate
      PresentationPurifiedrabbitpolyclonalinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.
      Applications
      ApplicationUseAnti-PCNAAntibody(RabbitPolyclonalAntibody)validatedinWB,ICCtodetectPCNAalsoknownasproliferatingcellnuclearantigen,cyclin,DNApolymerasedeltaauxiliaryprotein,Cyclin.
      KeyApplications
      • WesternBlotting
      • Immunocytochemistry
      ApplicationNotesWesternBlotAnalysis:1μg/mLfromapreviouslotdetectedPCNAon10μgofNIH/3T3andPC12celllysates.

      ImmunocytochemistryAnalysis:1:500dilutionfromapreviouslotdetectedPCNAinA431cells.
      BIOLOGicalInformation
      ImmunogenGST-taggedrecombinantproteincorrespondingtohumanPCNA.
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpeciesReactivity
      • Human
      • Mouse
      • Rat
      • Chimpanzee
      SpeciesReactivityNoteDemonstratedtoreactwithhuman,mouse,andrat.Predictedtoreactwithchimpanzeebasedon100%sequencehomology.Otherhomologies:Bovine,rabbit,canine,andpanda(99%sequencehomology).
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryTheproteinencodedbythisgeneisfoundinthenucleusandisacofactorofDNApolymerasedelta.TheencodedproteinactsasahomotrimerandhelpsincreasetheprocessivityofleadingstrandsynthesisduringDNAreplication.InresponsetoDNAdamage,thisproteinisubiquitinatedandisinvolvedintheRAD6-dependentDNArepairpathway.Twotranscriptvariantsencodingthesameproteinhavebeenfoundforthisgene.Pseudogenesofthisgenehavebeendescribedonchromosome4andontheXchromosome.[providedbyRefSeq].
      GeneSymbol
      • PCNA
      PurificationMethodProteinA
      UniProtNumber
      UniProtSummaryFUNCTION:ThisproteinisanauxiliaryproteinofDNApolymerasedeltaandisinvolvedinthecontrolofeukaryoticDNAreplicationbyincreasingthepolymerase"sprocessibilityduringelongationoftheleadingstrand.

      SUBUNITSTRUCTURE:Homotrimer(Bysimilarity).Formsacomplexwithactivator1heteropentamerinthepresenceofATP.InteractswithEXO1,POLH,POLK,DNMT1,ERCC5,FEN1,CDC6,APEX2andPOLDIP2.FormsaternarycomplexwithDNTTIP2andcorehistone.InteractswithKCTD10andPPP1R15A(Bysimilarity).InteractswithPOLD1,POLD3andPOLD4.InteractswithBAZ1B;theinteractionisdirect.InteractswithHLTFandSHPRH.InteractswithNUDT15.InteractionisdisruptedinresponsetoUVirradiationandacetylation.InteractswithCDKN1A/p21(CIP1)andCDT1;interactsviatheirPIP-boxwhichalsorecruitstheDCX(DTL)complex.

      SUBCELLULARLOCATION:Nucleus.

      PTM:Uponmethylmethanesulfonate-inducedDNAdamage,mono-ubiquitinatedbytheUBE2B-RAD18complexonLys-164.Thisinducesnon-canonicalpolyubiquitinationonLys-164through"Lys-63"linkageofubiquitinmoietiesbytheE2complexUBE2N-UBE2V2andtheE3ligases,HLTF,RNF8andSHPRH,whichisrequiredforDNArepair."Lys-63"polyubiquitinationpreventsgenomicinstABIlityonDNAdamage.MonoubiquitinationatLys-164alsotakesplaceinundamagedproliferatingcells,andismediatedbytheDCX(DTL)complex,leadingtoenhancePCNA-dependenttranslesionDNAsynthesis.

      AcetylatedinresponsetoUVirradiation.AcetylationdisruptsinteractionwithNUDT15andpromotesdegradation.

      MISCELLANEOUS:AntibodiesagainstPCNAarepresentinserafrompatientswithsystemiclupuserythematosus.

      SEQUENCESIMILARITIES:BelongstothePCNAfamily.
      MolecularWeight~35kDaobserved.PCNAhasapredictedmolecularweightof29kDa,however,itcanbemonoubiquitinated,resultingina~35kDaband.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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