| Immunogen | RatGSK3betasyntheticpeptide(aa.335-349),conjugatedtoKLH.Thissequenceis100%identicaltohumanGSK3beta. |
| Epitope | a.a.335-349 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | Thisantibodydetectsastrong47kDaprotein,correspondingtotheexpectedmolecularmassofGSK3beta. |
| Isotype | IgG |
| SpeciesReactivity | |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Glycogensynthasekinase-3(GSK3)isaproline-directedserine-threoninekinasethatwasinitiallyidentifiedasaphosphorylatingandnactivatingglycogensynthase.Twoisoforms,alpha(GSK3A;MIM606784)andbeta,showahighdegreeofaminoacidhomology(StambolicandWoodgett,1994[PubMed7980435]).GSK3Bisinvolvedinenergymetabolism,neuronalcelldevelopment,andbodypatternformation(Plyteetal.,1992[PubMed1333807]).[suppliedbyOMIM].
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| GeneSymbol | |
| PurificationMethod | ProteinAaffinitypurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:ParticipatesintheWntsignalingpathway.Implicatedinthehormonalcontrolofseveralregulatoryproteinsincludingglycogensynthase,MYBandthetranscriptionfactorJUN.PhosphorylatesJUNatsitesproximaltoitsDNA-bindingdomain,therebyreducingitsaffinityforDNA.PhosphorylatesMUC1inbreastcancercells,anddecreasestheinteractionofMUC1withCTNNB1/beta-catenin. CATALYTICACTIVITY:ATP+[tauprotein]=ADP+[tauprotein]phosphate. ENZYMEREGULATION:InhibitedwhenphosphorylatedbyAKT1. SUBUNIT:Monomer(Bysimilarity).InteractswithCABYR,MUC1,NINandPRUNE. ALTERNATIVEPRODUCTS:2namedisoforms[FASTA]producedbyalternativesplicing. |
| MolecularWeight | Thisantibodydetectsastrong47kDaprotein. |