| Immunogen | KLH-conjugated,syntheticpeptidecorrespondingtoaminoacids17-28ofHistoneH4.Epitopehasbeenmappedtoresidues25-28. | 
| Epitope | a.a.25-28 | 
| Clone | clone62-141-13 | 
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. | 
| Host | Rabbit | 
| Specificity | RecognizesHistoneH4,Mr10kDa. | 
| Isotype | IgG | 
| SpeciesReactivity | - Human
 - Chicken
 - Vertebrates
 - Yeast(S.cerevisiae)
 
  | 
| SpeciesReactivityNote | Human,chickenandyeast.Broadspeciescross-reactivityexpectedbasedonsequencehomology. | 
| AntibodyType | MonoclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | HistonesarebasicnuclearproteinsthatareresponsIBLeforthenucleosomestructureofthechromosomalfiberineukaryotes.Twomoleculesofeachofthefourcorehistones(H2A,H2B,H3,andH4)formanoctamer,aroundwhichapproximately146bpofDNAiswrappedinrepeatingunits,callednucleosomes.Thelinkerhistone,H1,interactswithlinkerDNAbetweennucleosomesandfunctionsinthecompactionofchromatinintohigherorderstructures.ThisgeneisintronlessandencodesamemberofthehistoneH4family.TranscriptsfromthisgenelackpolyAtailsbutinsteadcontainapalindromicterminationelement.Thisgeneisfoundinthelargehistonegeneclusteronchromosome6. | 
| GeneSymbol | - HIST1H4AH4/JHIST1H4FHIST1H4LH4FNH4FAH4FH
 - HIST1H4H
 - H4F2
 - H4FM
 - H4/A
 - H4FK
 - H4FG
 - HIST2H4
 - H4FB
 - H4/K
 - HIST1H4I
 - H4/N
 - HIST1H4B
 - H4FE
 - H4/M
 - H4/a
 - HIST1H4E
 - HIST4H4
 - HIST2H4A
 - H4FC
 - H4FI
 - H4/H
 - HIST1H4C
 - H4/G
 - HIST1H4K
 - H4FJ
 - H4FD
 - H4/I
 - H4/B
 - H4/D
 - H4/C
 - HIST1H4J
 - HIST1H4D
 - H4/E
 
  | 
| PurificationMethod | ProteinAPurfied | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:P62805#Corecomponentofnucleosome.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstABIlity.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling. SIZE:103aminoacids;11367Da SUBUNIT:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA. SUBCELLULARLOCATION:Nucleus. PTM:SymmetricdimethylationonArg-4bythePRDM1/PRMT5complexmayplayacrucialroleinthegerm-celllineage(Bysimilarity).&UbiquitinatedbytheCUL4-DDB-RBX1complexinresponsetoultravioletirrADIation.ThismayweakentheinteractionbetweenhistonesandDNAandfacilitateDNAaccessibilitytorepairproteins. SIMILARITY:SwissProt:P62805##BelongstothehistoneH4family. | 
| MolecularWeight | 10kDa |