| Immunogen | 6HisfusionproteincorrespondingtomousePML(promyelocyticleukemiaprotein) | 
| Clone | 36.1-104 | 
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. | 
| Host | Mouse | 
| Specificity | RecognizesPML. | 
| Isotype | IgG | 
| SpeciesReactivity |  | 
| AntibodyType | MonoclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | Theproteinencodedbythisgeneisamemberofthetripartitemotif(TRIM)family.TheTRIMmotifincludesthreezinc-bindingdomains,aRING,aB-boxtype1andaB-boxtype2,andacoiled-coilregion.Thisphosphoproteinlocalizestonuclearbodieswhereitfunctionsasatranscriptionfactorandtumorsuppressor.Itsexpressioniscell-cyclerelatedanditregulatesthep53responsetooncogenicsignals.Thegeneisofteninvolvedinthetranslocationwiththeretinoicacidreceptoralphageneassociatedwithacutepromyelocyticleukemia(APL).Extensivealternativesplicingofthisgeneresultsinseveralvariationsoftheprotein"scentralandC-terminalregions;allvariantsencodethesameN-terminus.Alternativelysplicedtranscriptvariantsencodingdifferentisoformshavebeenidentified. | 
| GeneSymbol |  | 
| PurificationMethod | ProteinGPurified | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:P29590#Probabletranscriptionfactor.MayplayanimportantroleinrecruitmentofELF4intoPMLnuclearbodies. SIZE:882aminoacids;97517Da
 SUBUNIT:InteractswithSIRT1,TOPBP1,TRIM27andTRIM69.InteractswiththeC-terminusofELF4.InteractswithLassavirusZproteinandrABIesvirusphosphoprotein(Bysimilarity).
 SUBCELLULARLOCATION:Nucleus.Note=LocalizedtoPMLnuclearbodies.
 PTM:Ubiquitinated;mediatedbySIAH1orSIAH2andleADIngtoitssubsequentproteasomaldegradation.
 DISEASE:SwissProt:P29590#AchromosomalaberrationinvolvingPMLmaybeacauseofacutepromyelocyticleukemia(APL).Translocationt(15;17)(q21;q21)withRARA.ThePMLbreakpoints(typeAandtypeB)lieoneithersideofanalternativelysplicedexon.
 SIMILARITY:SwissProt:P29590##Contains2Bbox-typezincfingers.&Contains1RING-typezincfinger.
 | 
| MolecularWeight | 90-106kDa |